For the first time, the American Society of Clinical Oncology (ASCO) has formally stated that alcohol drinking is a risk factor for multiple malignancies.
Furthermore, the organisation believes their new “proactive stance” to minimise excessive alcohol intake has “important implications for cancer prevention.”
“Even modest use of alcohol may increase cancer risk, but the greatest risks are observed with heavy, long-term use,” write the ASCO statement authors, led by Noelle LoConte, MD, from the University of Wisconsin-Madison.
“Therefore, limiting alcohol intake is a means to prevent cancer,” Dr. LoConte said in a statement. “The good news is that, limiting alcohol intake is one more thing people can do to reduce their overall risk of developing cancer.”
ASCO’s statement, published online November 6 in the Journal of Clinical Oncology, has received widespread coverage in mainstream media.
But don’t shoot the messenger. And don’t get upset. “The message is not, ‘Don’t drink.’ It is ‘If you want to reduce your cancer risk, drink less. But if you don’t drink, don’t start,'” Dr. LoConte told The New York Times.
ASCO encourages oncologists to join their efforts: “Oncology providers can serve as community advisors and leaders, and can help raise the awareness of alcohol as a cancer risk behavior.”
However, the organisation also says there is “low physician knowledge of alcohol use and cancer risk.”
The general public also has low awareness. In a recent poll conducted by ASCO, 70% of the questioned did not recognise drinking alcohol as a cancer risk factor, as reported by Medscape Medical News.
“People typically don’t associate drinking beer, wine and hard liquor with increasing their risk of developing cancer in their lifetimes,” said ASCO President Bruce Johnson, MD. “However, the link between increased alcohol consumption and cancer has been firmly established.”
In its statement, ASCO notes that alcohol consumption is causally associated with oropharyngeal and laryngeal cancer, esophageal cancer, hepatocellular carcinoma, breast cancer and colon cancer. However, alcohol may also be a risk factor for other malignancies, including pancreatic and gastric cancers.
In total, ASCO estimates that 5% to 6% of new cancers and cancer deaths globally are directly attributable to alcohol.
A variety of causative mechanisms may be at play, depending on the particular cancer. Perhaps best known is the effect of alcohol on circulating estrogens, a pathway with relevance to breast cancer.
The American Heart Association, American Cancer Society and the US Department of Health and Human Services currently recommend that men limit intake to one to two drinks per day and women to one drink per day.
However, the ASCO statement authors observe that a meta-analysis found that one drink per day or less was still associated with some elevated risk for squamous cell carcinoma of the esophagus, oropharyngeal cancer and breast cancer (Ann Oncol. 2013;24:301-308).
Defining risk-drinking can be “challenging,” say the statement authors, because the amount of ethanol in a drink varies depending on the type of alcohol (eg. beer, wine or spirits) and its size.
Conflicting data about the impact of alcohol, especially red wine, on the heart is an “additional barrier” to addressing its related cancer risk. But recent research (Addiction. 2017;112:230-232) has cast doubt on those positive health claims studies, revealing multiple confounders, including frequent classification of former and occasional alcohol drinkers as nondrinkers, say the statement authors.
ASCO says that it joins a “growing number” of cancer care and public health organisations that support strategies designed to prevent high-risk alcohol consumption. Its statement offers evidence-based policy recommendations to reduce excessive alcohol consumption, as follows:
- Provide alcohol screening and brief interventions in clinical settings.
- Regulate alcohol outlet density.
- Increase alcohol taxes and prices.
- Maintain limits on days and hours of sale.
- Enhance enforcement of laws prohibiting sales to minors.
- Restrict youth exposure to advertising of alcoholic beverages.
- Resist further privatisation of retail alcohol sales in communities with current government control.
- Include alcohol control strategies in comprehensive cancer control plans.
- Support efforts to eliminate the use of “pinkwashing” to market alcoholic beverages (ie, discouraging alcoholic beverage companies from exploiting the colour pink or pink ribbons to show a commitment to finding a cure for breast cancer, given the evidence that alcohol consumption is linked to an increased risk for breast cancer).
Besides, alcohol stresses our liver, cuts down consciousness, etc. etc. I don’t drink and actually believe that alcohol is a drug that should be banned. There, I said it…